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Eight Effective Brain Exercises to Boost Cognitive Function
Reading Time: 7 minutes. Get ready to boost your brain power! In this article, you’ll discover eight effective brain exercises that can enhance your cognitive function. These exercises are backed by scientific research and designed to engage your brain in active and meaningful ways. From memory-boosting exercises to problem-solving activities, attention and focus training, and…
Methylene Blue and Drug Interactions: SSRIs, SNRIs, and Contraindications
Reading Time: 9 minutes. Methylene blue acts as a potent MAO-A inhibitor that concentrates in the brain, which is why combining it with SSRIs, SNRIs, or other serotonergic drugs risks serotonin syndrome. The FDA guidance is clear: avoid coadministration unless the benefits outweigh the risks. If use is unavoidable, discontinue serotonergic drugs first, observe appropriate…
Methylene Blue and ALS (Amyotrophic Lateral Sclerosis): Hope or Hype?
Reading Time: 6 minutes. Despite methylene blue‘s compelling biochemical rationale—it enhances mitochondrial function, reduces oxidative stress, and dampens neuroinflammation—you’ll find its track record in ALS research disappointingly underwhelming. The compound showed no survival benefit or motor improvement in SOD1(G93A) mouse models, the gold standard for preclinical ALS testing. While simpler organisms, such as C. elegans,…
Methylene Blue and Anxiety: What the Research Says About Stress and Resilience
Reading Time: 10 minutes. Methylene blue shows promise as a low-dose, mitochondria-targeted adjunct for anxiety. It preserves neuronal ATP via redox cycling, improves cerebral oxygenation, and reduces oxidative stress. Modest, reversible MAO-A/B inhibition may aid mood and attention, with small studies noting improvements in memory and vigilance. It can enhance fear extinction, supporting exposure-based therapies.…
Methylene Blue With Nad+: Exploring Synergy in Cellular Energy Support
Reading Time: 6 minutes. Methylene blue (MB) and NAD+ exhibit complementary redox roles that stabilise mitochondrial electron transport. NAD+ accepts hydrides in the Krebs cycle, sustaining Complex I activity, while low-dose MB shuttles electrons and oxidises NADH/NADPH, preserving ATP synthesis under stress. MB transiently activates AMPK and protects telomeres; NAD+ supports sirtuins and PARPs for…
How Long Is It Safe to Take Methylene Blue?
Reading Time: 16 minutes. The safe duration for taking methylene blue varies based on your medical condition and treatment goals. For acute conditions like methemoglobinemia, a single dose of 1 mg/kg is typically sufficient. However, for conditions such as ifosfamide-induced encephalopathy, you may require treatment for s everal days at 50 mg every 4-8 hours,…
