Your basket is currently empty!
Methylene Blue and Serotonin/MAOI Risks
Reading Time: 6 minutes. Methylene blue is the first-line, FDA-approved antidote for acquired methemoglobinemia. It accelerates the NADPH-dependent reduction of ferric (Fe3+) to ferrous (Fe2+) haemoglobin via leuco-methylene blue, rapidly restoring the oxygen-carrying capacity. Indicated when methemoglobin levels are≥20–30% or earlier if symptomatic, dosing is 1–2 mg/kg IV (lower in paediatrics), repeatable once. Risks include…
Methylene Blue and the Immune System: Mechanisms, Evidence, and Considerations
Reading Time: 12 minutes. Methylene blue modulates immunity by inhibiting iNOS/NO signalling, suppressing NF-κB and inflammasome activation, and reducing the production of IL-1β, IL-18, IL-6, and MCP-1. It stabilises mitochondrial respiration as an alternative electron carrier, lowers ROS, and boosts ATP, aiding immune cell energetics. It tempers macrophage/neutrophil activation, as well as MMP release. Clinically,…
Unlocking the Secrets of Biohacking for a Healthier Life
Reading Time: 7 minutes. Biohacking combines data-driven experimentation with scientific enhancement to elevate your biological potential. You’ll need to understand your personal biology through self-testing and targeted interventions in sleep, nutrition, and environment. Key strategies include maintaining ideal bedroom temperatures (18-20°C), using True Dark glasses to manage circadian rhythms, and implementing precise meal timing. Modern…
Unlocking the Secrets of Brain Health in the Age of Tech Overload
Reading Time: 6 minutes. As we navigate through the digital age, the imperative to understand and protect our brain health has become increasingly evident. The proliferation of technology has not only altered our daily habits but also raised concerns about the potential impact on our cognitive well-being. This exploration seeks to unravel the complexities of…
Improving Sports Performance with Methylene Blue
Reading Time: 10 minutes. Some may baulk at the idea, but methylene blue isn’t just a dye. It’s a potential game-changer in sports performance. This article explores how athletes can safely use it to boost cognitive function, alleviate brain fog, and enhance energy production. Don’t you want to be part of this cutting-edge revolution? Dive…
Administering Methylene Blue: Methods and Best Practices
Reading Time: 15 minutes. You’ll need to administer methylene blue primarily through IV infusion over 5-30 minutes, diluted with 50 mL of 5% Dextrose Injection. For the treatment of adult methemoglobinemia, use 1 mg/kg IV; pediatric doses range from 0.3 to 1 mg/kg. Do not use sodium chloride solutions for dilution. You must continuously monitor…
Unlocking the Secrets of Nutrition for Mental Well-Being
Reading Time: 6 minutes. Your diet plays a crucial role in your mental well-being, as specific nutrients have a direct impact on brain chemistry and cognitive function. Research indicates that B vitamins, omega-3 fatty acids, and Vitamin D significantly impact mood regulation, memory, and emotional stability. Your brain consumes approximately 20% of your body’s energy,…
Methylene Blue and Methemoglobinemia: Medical Uses and Risks
Reading Time: 6 minutes. Methylene blue is the first-line, FDA-approved antidote for acquired methemoglobinemia. It accelerates the NADPH-dependent reduction of ferric (Fe3+) to ferrous (Fe2+) haemoglobin via leucomethylene blue, rapidly restoring oxygen-carrying capacity. Indicated when methemoglobin levels are≥20–30% or earlier if symptomatic, dosing is 1–2 mg/kg IV (lower in paediatrics), repeatable once. Risks include hemolysis…
Who Should Avoid Methylene Blue? Key Safety Guidelines
Reading Time: 23 minutes. Methylene blue is contraindicated in several patient populations due to significant safety risks. Pregnant women must avoid it entirely (FDA Category X) due to potential fetal harm. Patients with G6PD deficiency face severe hemolysis risks, requiring mandatory screening before treatment. Those taking serotonergic medications (SSRIs, SNRIs, TCAs) must observe a two-week…
Unlocking the Healing Potential of Methylene Blue
Reading Time: 7 minutes. I’ve found that methylene blue has evolved from its 19th-century origins as a textile dye into a remarkable therapeutic compound with diverse medical applications. Research shows it can enhance cognitive function, support mitochondrial health, and act as a powerful antioxidant and antiviral agent. It works by crossing the blood-brain barrier and…
