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Methylene Blue and Huntington’s Disease: What Research Reveals
Reading Time: 9 minutes. Research shows that methylene blue disrupts huntingtin protein aggregates that cause Huntington’s disease by interfering with hydrogen-bonding networks and β-sheet formation. Studies demonstrate it effectively blocks aggregate formation in cell cultures, extends lifespan in Drosophila models, and delays symptom onset in R6/2 mice when treatment begins early. The compound also enhances…
Is Long-Term Methylene Blue Use Safe? Contraindications, Daily Dosing Risks, and What Research Really Shows
Reading Time: 21 minutes. Long-term methylene blue use appears safe at therapeutic doses of 0.5-2 mg/kg body weight, with typical protocols using 10-30 mg daily for neurological benefits. Research indicates doses exceeding 5 mg/kg approach toxic territory, causing cardiovascular, gastrointestinal, and haematological complications. The compound exhibits a narrow therapeutic window, where low doses enhance mitochondrial…
Methylene Blue and ALS (Amyotrophic Lateral Sclerosis): Hope or Hype?
Reading Time: 6 minutes. Despite methylene blue‘s compelling biochemical rationale—it enhances mitochondrial function, reduces oxidative stress, and dampens neuroinflammation—you’ll find its track record in ALS research disappointingly underwhelming. The compound showed no survival benefit or motor improvement in SOD1(G93A) mouse models, the gold standard for preclinical ALS testing. While simpler organisms, such as C. elegans,…
Methylene Blue and Kidney Health: Is There a Risk?
Reading Time: 15 minutes. Methylene blue demonstrates both therapeutic potential and significant risks for kidney health. Clinical studies demonstrate nephroprotective properties through the modulation of redox reactions and activation of the Nrf2/ARE pathway, resulting in documented improvements in creatinine clearance and a reduction in tubular injury markers. However, strict medical supervision is essential due to toxicity…
Methylene Blue and Kidney Health: Risks and Precautions
Reading Time: 14 minutes. Methylene blue has been used safely for over a century in various medical applications, and emerging research suggests it may offer protective benefits for kidney health through its potent antioxidant properties. When used at appropriate low doses for cognitive enhancement—such as the 0.5-2 mg/kg range typical in nootropic applications like Blu…
Understanding the Potential Risks of Using Methylene Blue
Reading Time: 17 minutes. Methylene blue presents multiple significant medical risks requiring careful clinical consideration. Key concerns include cardiovascular complications, central nervous system effects, and gastrointestinal disturbances. The medication can trigger severe allergic reactions, including anaphylactic shock, characterised by respiratory distress and cardiovascular instability. Notable drug interactions exist, particularly with serotonergic medications, potentially leading to…
