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Safe Methylene Blue Dosages: How Much Should You Take?
Reading Time: 15 minutes. Your safe methylene blue dosage depends on your specific medical condition and route of administration. For IV treatment of methemoglobinaemia, you’ll need 1 mg/kg over 5-30 minutes, with a possible repeat dose after one hour. If you’re taking MB oral supplements, such as Blu Brain, start with 10 mg daily, not…
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Taking Methylene Blue Daily: Is It Safe?
Reading Time: 6 minutes. Taking methylene blue daily requires strict medical supervision and careful adherence to dosing guidelines. While therapeutic doses typically range from 10-30mg daily, improper use can lead to serious complications, including methemoglobinemia, serotonin syndrome, and severe reactions in people with G6PD deficiency. Common side effects include blue-green urine, dizziness, and confusion. The…
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Understanding Long-Term Risks of Methylene Blue Usage
Reading Time: 14 minutes. Long-term exposure to methylene blue poses significant health risks, necessitating careful monitoring. Chronic use can lead to cumulative oxidative stress, affecting the cardiovascular, renal, and neurological systems. At doses exceeding 5 mg/kg, patients risk developing methemoglobinemia, serotonin toxicity, and severe organ complications. The compound exhibits a biphasic response: while low doses…
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Methylene Blue and Long Covid: Current Theories and Ongoing Research
Reading Time: 11 minutes. Methylene blue is being explored for Long COVID due to antiviral actions (spike–ACE2 blockade, Zn2+ ionophore effects, RdRp inhibition, lysosomal pH elevation) and immunomodulation (NLRP3, NF-κB, PD-1–SHP2). In vitro data show low micromolar inhibition; small acute COVID-19 trials suggest improved SpO2 and inflammatory markers without a clear mortality benefit. Its mitochondrial…
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Methylene Blue and Depression: Could It Be a Novel Treatment?
Reading Time: 10 minutes. Methylene blue shows genuine promise as a depression treatment, with controlled trials demonstrating effect sizes of 0.71-0.80 at 300mg doses—comparable to FDA-approved antidepressants. You’ll find that it works through multiple mechanisms, including enhancing mitochondrial function, inhibiting monoamine oxidase A, and modulating nitric oxide pathways. It’s even shown effectiveness in bipolar depression…
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Methylene Blue and G6PD Deficiency: Why It Can Be Unsafe
Reading Time: 6 minutes. Methylene blue treats methemoglobinemia via NADPH-dependent reduction to leucomethylene blue. In G6PD deficiency, NADPH is insufficient, so the drug cannot reduce methemoglobin and instead amplifies oxidative stress. This triggers Heinz body formation, acute hemolysis, and can worsen hypoxia. FDA labelling lists G6PD deficiency as a contraindication. Warning signs include dark urine,…
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Unlocking the Power of Mind-Body Harmony for Wellness
Reading Time: 7 minutes. Your mind and body form an intricate partnership that directly influences your overall wellness. Through the vagus nerve, your thoughts and emotions elicit physical responses that affect everything from heart rate to immune function. You can enhance this connection through simple daily practices, such as mindful breathing, movement meditation, and emotional…
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Methylene Blue Vs DLPA: Comparing Mechanisms, Benefits, and Safety
Reading Time: 8 minutes. Methylene blue is FDA‑approved for methemoglobinemia and hospital‑supervised; DLPA is an OTC supplement. Methylene blue inhibits MAO‑A and nitric oxide synthases, supports mitochondria, and can modestly enhance memory at low doses, but risks serotonin toxicity and is contraindicated in G6PD deficiency and pregnancy. DLPA combines D- and L-phenylalanine to prolong endorphins…
Methylene Blue 1% Mind Booster
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Learn about the intricate relationship between the gut and the brain and how the two influence each other’s health and cognitive function.