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Is Long-Term Methylene Blue Use Safe? Contraindications, Daily Dosing Risks, and What Research Really Shows
Reading Time: 21 minutes. Long-term methylene blue use appears safe at therapeutic doses of 0.5-2 mg/kg body weight, with typical protocols using 10-30 mg daily for neurological benefits. Research indicates doses exceeding 5 mg/kg approach toxic territory, causing cardiovascular, gastrointestinal, and haematological complications. The compound exhibits a narrow therapeutic window, where low doses enhance mitochondrial…
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World Mental Health Day 2025: How Our Environment Shapes Brain Health
Reading Time: 14 minutes. Our surroundings are not neutral backdrops; they actively shape the way our brains grow and age. The constant assault of urban noise and polluted air inflames the nervous system, disrupts sleep, and drives up rates of anxiety and depression. On the other hand, when we raise children near parks and trees,…
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Methylene Blue for Anxiety and Mood Disorders: Evidence and Limitations
Reading Time: 11 minutes. Methylene blue shows promise for anxiety through its mitochondrial-enhancing effects, particularly improving fear extinction in claustrophobia trials at 260 mg doses. You’ll find evidence suggesting enhanced memory consolidation and ATP production in neural circuits, though research remains limited by inconsistent dosing protocols and variable patient responses. It’s contraindicated if you’re taking…
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Methylene Blue and ALS (Amyotrophic Lateral Sclerosis): Hope or Hype?
Reading Time: 6 minutes. Despite methylene blue‘s compelling biochemical rationale—it enhances mitochondrial function, reduces oxidative stress, and dampens neuroinflammation—you’ll find its track record in ALS research disappointingly underwhelming. The compound showed no survival benefit or motor improvement in SOD1(G93A) mouse models, the gold standard for preclinical ALS testing. While simpler organisms, such as C. elegans,…
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Unlocking the Secrets of Sleep: Mechanisms and Strategies
Reading Time: 7 minutes. Your sleep quality depends on adenosine buildup throughout the day, creating sleep pressure that signals when it’s time to rest. Physical activity enhances this process, while caffeine disrupts it by blocking adenosine receptors. You’ll need different amounts of sleep based on your age, genetics, and activity level, with most adults requiring…
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Navigating Neuroscience: Insights From Dr Daryl Wild
Reading Time: 6 minutes. Dr Daryl Wild’s journey from psychology to neuroscience exemplifies how personal experiences shape scientific expertise. You’ll find his shift was catalysed by family health challenges, leading to the establishment of the Okanagan Movement Disorder Clinic in 2015. His innovative approaches combine psychological insights with neurological applications, particularly in movement disorders and…
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Unlocking Brain Health: Strategies for Vitality and Growth
Reading Time: 6 minutes. Our brains possess remarkable neuroplasticity, enabling continuous growth and adaptation throughout life. We can enhance cognitive function through targeted strategies, including quality sleep, stress management, and mentally stimulating activities. Neuroimaging research confirms that lifestyle interventions strengthen neural pathways and support cognitive resilience. We will reveal our neural potential by prioritising brain health through evidence-based…
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Unlocking Brain Health: Strategies for a Vibrant Mind
Reading Time: 6 minutes. You enhance your brain health by adopting key lifestyle habits. Regular exercise improves cognitive resilience. A balanced diet rich in whole foods supports brain function. Getting enough sleep, typically 7 to 9 hours, is essential for optimal performance. Mentally stimulating activities and mindfulness practices also boost brain health. You’ll build a…
Methylene Blue 1% Mind Booster
