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Methylene Blue and Depression: Could It Be a Novel Treatment?
Reading Time: 10 minutes. Methylene blue shows genuine promise as a depression treatment, with controlled trials demonstrating effect sizes of 0.71-0.80 at 300mg doses—comparable to FDA-approved antidepressants. You’ll find that it works through multiple mechanisms, including enhancing mitochondrial function, inhibiting monoamine oxidase A, and modulating nitric oxide pathways. It’s even shown effectiveness in bipolar depression…
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Methylene Blue and G6PD Deficiency: Why It Can Be Unsafe
Reading Time: 6 minutes. Methylene blue treats methemoglobinemia via NADPH-dependent reduction to leucomethylene blue. In G6PD deficiency, NADPH is insufficient, so the drug cannot reduce methemoglobin and instead amplifies oxidative stress. This triggers Heinz body formation, acute hemolysis, and can worsen hypoxia. FDA labelling lists G6PD deficiency as a contraindication. Warning signs include dark urine,…
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Methylene Blue Vs DLPA: Comparing Mechanisms, Benefits, and Safety
Reading Time: 8 minutes. Methylene blue is FDA‑approved for methemoglobinemia and hospital‑supervised; DLPA is an OTC supplement. Methylene blue inhibits MAO‑A and nitric oxide synthases, supports mitochondria, and can modestly enhance memory at low doses, but risks serotonin toxicity and is contraindicated in G6PD deficiency and pregnancy. DLPA combines D- and L-phenylalanine to prolong endorphins…
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Methylene Blue for Sports Performance: A Guide for Athletes and Endurance Training
Reading Time: 9 minutes. Methylene blue is an FDA-approved redox agent that, at low doses, supports mitochondrial electron transport, increases ATP production, and can enhance endurance and cognitive performance. Typical protocols start at 4–8 mg, titrating to 8 mg twice daily, taken 30–60 minutes pre‑workout. Quality sourcing is essential. Avoid with SSRIs/SNRIs, in G6PD deficiency,…
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Methylene Blue Vs Caffeine: Cognitive Benefits, Energy, and Key Differences
Reading Time: 6 minutes. Methylene blue enhances cognition by stabilising mitochondrial electron cycling, thereby stabilising ATP and reducing oxidative stress. Small trials suggest improved memory and processing under load, with steadier effects. Caffeine blocks adenosine receptors, increasing arousal, attention, and reaction time; however, tolerance and rebound fatigue are common, with sleep disruption occurring at higher doses.…
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Methylene Blue for Students: Memory, Focus, and Learning Support
Reading Time: 10 minutes. Methylene blue may support memory and focus at low doses by enhancing mitochondrial respiration, stabilising ATP supply, and modulating task-evoked brain activity. Small randomised trials have shown modest retrieval gains and improved network-specific activation within one hour. Benefits appear to be dose-dependent, with low doses being favoured; higher amounts can blunt…
Methylene Blue 1% Mind Booster
Tag: Methylene Blue
Gain insights into the potential benefits and uses of methylene blue in supporting brain health, cognitive function, and neuroprotection.