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Methylene Blue and Stroke: Can It Protect the Brain and Aid Recovery?
Reading Time: 9 minutes. Methylene blue shows promise for protecting your brain during stroke by stabilising mitochondrial function and enhancing ATP production, even in oxygen-deprived tissue. In experimental models, it has reduced infarct volumes by 30-50% and extended the therapeutic window when administered within 60 minutes of stroke onset. The compound acts as an alternative electron…
Methylene Blue and Huntington’s Disease: What Research Reveals
Reading Time: 9 minutes. Research shows that methylene blue disrupts huntingtin protein aggregates that cause Huntington’s disease by interfering with hydrogen-bonding networks and β-sheet formation. Studies demonstrate it effectively blocks aggregate formation in cell cultures, extends lifespan in Drosophila models, and delays symptom onset in R6/2 mice when treatment begins early. The compound also enhances…
Methylene Blue and Multiple Sclerosis: Early Findings and Potential Benefits
Reading Time: 8 minutes. Methylene blue enhances your mitochondrial function by increasing complex IV activity and ATP synthesis while reducing oxidative stress in neural tissue. It’s demonstrated neuroprotective effects in experimental autoimmune encephalomyelitis models, significantly reducing demyelination and preserving myelin proteins. You’ll find that it modulates immune responses by inhibiting IL-6 secretion and restoring the…
Is Long-Term Methylene Blue Use Safe? Contraindications, Daily Dosing Risks, and What Research Really Shows
Reading Time: 21 minutes. Long-term methylene blue use appears safe at therapeutic doses of 0.5-2 mg/kg body weight, with typical protocols using 10-30 mg daily for neurological benefits. Research indicates doses exceeding 5 mg/kg approach toxic territory, causing cardiovascular, gastrointestinal, and haematological complications. The compound exhibits a narrow therapeutic window, where low doses enhance mitochondrial…
The Fountain of Youth for Our Cells? Let’s Discuss the Latest Anti-Ageing Studies
Reading Time: 3 minutes. Hey everyone! I’ve recently come across some intriguing studies on methylene blue and its potential anti-ageing effects on our cells. Ever heard of it? Let me break down what I’ve found in a way that’s easy to digest and hopefully sparks some interesting discussions. What is Methylene Blue? Methylene blue, a…
Share Your Experiences With Cognitive Enhancement Stacks
Reading Time: 4 minutes. Hey brain health enthusiasts! Have you ever wondered how certain supplements can help sharpen your mind and enhance your cognitive abilities? I’ve been delving into the world of nootropics, and I’m excited to share what I’ve learned about two popular choices: L-theanine and creatine. Let’s unpack these cognitive enhancers and see…
What Science Reveals About Methylene Blue Benefits: From Brain Power and Mitochondrial Energy to Emerging Health Uses
Reading Time: 11 minutes. Science suggests methylene blue can shuttle electrons in the mitochondrial chain, support ATP production, and limit reactive oxygen species via redox cycling. Small trials report modest gains in memory and attention, alongside neuroprotective signals. It is FDA‑approved for methemoglobinemia and used in select surgical contexts. Yet, dosing windows are narrow, MAO…
World Mental Health Day 2025: How Our Environment Shapes Brain Health
Reading Time: 14 minutes. Our surroundings are not neutral backdrops; they actively shape the way our brains grow and age. The constant assault of urban noise and polluted air inflames the nervous system, disrupts sleep, and drives up rates of anxiety and depression. On the other hand, when we raise children near parks and trees,…
How to Use Methylene Blue Safely: Dosage by Weight, Risk Factors, and the Blu Brain Calculator
Reading Time: 16 minutes. Methylene blue is a redox-active antidote for methemoglobinemia dosed by weight. Typical dosing is 1 mg/kg IV over 5–30 minutes, diluted in 5% dextrose; avoid sodium chloride. Do not exceed 5 mg/kg/day or 7 mg/kg cumulative (stricter: ≤4 mg/kg for aniline/dapsone). In paediatrics, standard doses are 0.3–1 mg/kg with a single…
