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Is Long-Term Methylene Blue Use Safe? Contraindications, Daily Dosing Risks, and What Research Really Shows
Reading Time: 21 minutes. Long-term methylene blue use appears safe at therapeutic doses of 0.5-2 mg/kg body weight, with typical protocols using 10-30 mg daily for neurological benefits. Research indicates doses exceeding 5 mg/kg approach toxic territory, causing cardiovascular, gastrointestinal, and haematological complications. The compound exhibits a narrow therapeutic window, where low doses enhance mitochondrial…
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The Fountain of Youth for Our Cells? Let’s Discuss the Latest Anti-Ageing Studies
Reading Time: 3 minutes. Hey everyone! I’ve recently come across some intriguing studies on methylene blue and its potential anti-ageing effects on our cells. Ever heard of it? Let me break down what I’ve found in a way that’s easy to digest and hopefully sparks some interesting discussions. What is Methylene Blue? Methylene blue, a…
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Share Your Experiences With Cognitive Enhancement Stacks
Reading Time: 4 minutes. Hey brain health enthusiasts! Have you ever wondered how certain supplements can help sharpen your mind and enhance your cognitive abilities? I’ve been delving into the world of nootropics, and I’m excited to share what I’ve learned about two popular choices: L-theanine and creatine. Let’s unpack these cognitive enhancers and see…
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What Science Reveals About Methylene Blue Benefits: From Brain Power and Mitochondrial Energy to Emerging Health Uses
Reading Time: 11 minutes. Science suggests methylene blue can shuttle electrons in the mitochondrial chain, support ATP production, and limit reactive oxygen species via redox cycling. Small trials report modest gains in memory and attention, alongside neuroprotective signals. It is FDA‑approved for methemoglobinemia and used in select surgical contexts. Yet, dosing windows are narrow, MAO…
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World Mental Health Day 2025: How Our Environment Shapes Brain Health
Reading Time: 14 minutes. Our surroundings are not neutral backdrops; they actively shape the way our brains grow and age. The constant assault of urban noise and polluted air inflames the nervous system, disrupts sleep, and drives up rates of anxiety and depression. On the other hand, when we raise children near parks and trees,…
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How to Use Methylene Blue Safely: Dosage by Weight, Risk Factors, and the Blu Brain Calculator
Reading Time: 16 minutes. Methylene blue is a redox-active antidote for methemoglobinemia dosed by weight. Typical dosing is 1 mg/kg IV over 5–30 minutes, diluted in 5% dextrose; avoid sodium chloride. Do not exceed 5 mg/kg/day or 7 mg/kg cumulative (stricter: ≤4 mg/kg for aniline/dapsone). In paediatrics, standard doses are 0.3–1 mg/kg with a single…
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Methylene Blue and ALS (Amyotrophic Lateral Sclerosis): Hope or Hype?
Reading Time: 6 minutes. Despite methylene blue‘s compelling biochemical rationale—it enhances mitochondrial function, reduces oxidative stress, and dampens neuroinflammation—you’ll find its track record in ALS research disappointingly underwhelming. The compound showed no survival benefit or motor improvement in SOD1(G93A) mouse models, the gold standard for preclinical ALS testing. While simpler organisms, such as C. elegans,…
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Methylene Blue and Anxiety: What the Research Says About Stress and Resilience
Reading Time: 10 minutes. Methylene blue shows promise as a low-dose, mitochondria-targeted adjunct for anxiety. It preserves neuronal ATP via redox cycling, improves cerebral oxygenation, and reduces oxidative stress. Modest, reversible MAO-A/B inhibition may aid mood and attention, with small studies noting improvements in memory and vigilance. It can enhance fear extinction, supporting exposure-based therapies.…
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Methylene Blue With Nad+: Exploring Synergy in Cellular Energy Support
Reading Time: 6 minutes. Methylene blue (MB) and NAD+ exhibit complementary redox roles that stabilise mitochondrial electron transport. NAD+ accepts hydrides in the Krebs cycle, sustaining Complex I activity, while low-dose MB shuttles electrons and oxidises NADH/NADPH, preserving ATP synthesis under stress. MB transiently activates AMPK and protects telomeres; NAD+ supports sirtuins and PARPs for…
Methylene Blue 1% Mind Booster
Tag: neuroprotection
Discover strategies and interventions aimed at protecting the brain from damage, promoting brain health, and reducing the risk of neurodegenerative diseases.
