Your basket is currently empty!
Methylene Blue Safety Explained: Contraindications, Pregnancy Risks, Drug Interactions, and Daily Use Guidelines
Reading Time: 19 minutes. Methylene blue exhibits significant therapeutic utility in specific clinical scenarios; however, its safety profile necessitates rigorous assessment prior to administration. Absolute contraindications include glucose-6-phosphate dehydrogenase deficiency, severe renal impairment, and documented hypersensitivity reactions. The compound carries a Pregnancy Category X classification due to established teratogenic effects and elevated fetal mortality rates,…
Top Vitamin for Boost Energy: Enhance Your Daily Vitality
Reading Time: 9 minutes. B vitamins reign supreme for energy enhancement, with B12, B6, and folate playing crucial roles in converting food into cellular fuel. These powerhouses facilitate red blood cell formation, optimise metabolic reactions, and support proper oxygen transport throughout your body. For maximum vitality, pair these nutrients with vitamin C, magnesium, iron, and…
The Efficacy of Blue Light Cystoscopy Over White Light
Reading Time: 7 minutes. Bladder cancer is a prevalent and potentially life-threatening condition that requires accurate and reliable diagnostic tools. In recent years, the use of blue light cystoscopy (BLC) has emerged as a promising technique for the detection of bladder cancer, surpassing the limitations of traditional white light cystoscopy (WLC). This article aims to…
Methylene Blue and Kidney Health: Risks and Precautions
Reading Time: 14 minutes. Methylene blue has been used safely for over a century in various medical applications, and emerging research suggests it may offer protective benefits for kidney health through its potent antioxidant properties. When used at appropriate low doses for cognitive enhancement—such as the 0.5-2 mg/kg range typical in nootropic applications like Blu…
Unravelling Cancer: Lifestyle, Metabolism, and Prevention
Reading Time: 7 minutes. Recent evidence suggests cancer operates primarily as a metabolic disorder, not just a genetic disease. You’ll find that lifestyle factors considerably impact your cellular metabolism and mitochondrial function, with traditional societies exhibiting remarkably lower cancer rates. Through strategic nutritional interventions, regular physical activity, and reduced exposure to environmental toxins, you can…
Methylene Blue and the Immune System: Mechanisms, Evidence, and Considerations
Reading Time: 12 minutes. Methylene blue modulates immunity by inhibiting iNOS/NO signalling, suppressing NF-κB and inflammasome activation, and reducing the production of IL-1β, IL-18, IL-6, and MCP-1. It stabilises mitochondrial respiration as an alternative electron carrier, lowers ROS, and boosts ATP, aiding immune cell energetics. It tempers macrophage/neutrophil activation, as well as MMP release. Clinically,…
Methylene Blue Mechanism of Action: How It Works in the Body
Reading Time: 11 minutes. Methylene blue is a redox-active electron shuttle. It accepts electrons from NADPH/NADH to form leucomethylene blue, which reduces Fe3+ methemoglobin to functional Fe2+ haemoglobin. In mitochondria, it bypasses impaired complexes, enhances cytochrome c oxidase efficiency, sustains ATP production, and limits superoxide production. It inhibits NO-stimulated soluble guanylyl cyclase, restoring vascular tone…
