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Methylene Blue and Huntington’s Disease: What Research Reveals
Reading Time: 9 minutes. Research shows that methylene blue disrupts huntingtin protein aggregates that cause Huntington’s disease by interfering with hydrogen-bonding networks and β-sheet formation. Studies demonstrate it effectively blocks aggregate formation in cell cultures, extends lifespan in Drosophila models, and delays symptom onset in R6/2 mice when treatment begins early. The compound also enhances…
Is Long-Term Methylene Blue Use Safe? Contraindications, Daily Dosing Risks, and What Research Really Shows
Reading Time: 21 minutes. Long-term methylene blue use appears safe at therapeutic doses of 0.5-2 mg/kg body weight, with typical protocols using 10-30 mg daily for neurological benefits. Research indicates doses exceeding 5 mg/kg approach toxic territory, causing cardiovascular, gastrointestinal, and haematological complications. The compound exhibits a narrow therapeutic window, where low doses enhance mitochondrial…
World Mental Health Day 2025: How Our Environment Shapes Brain Health
Reading Time: 14 minutes. Our surroundings are not neutral backdrops; they actively shape the way our brains grow and age. The constant assault of urban noise and polluted air inflames the nervous system, disrupts sleep, and drives up rates of anxiety and depression. On the other hand, when we raise children near parks and trees,…
Methylene Blue and ALS (Amyotrophic Lateral Sclerosis): Hope or Hype?
Reading Time: 6 minutes. Despite methylene blue‘s compelling biochemical rationale—it enhances mitochondrial function, reduces oxidative stress, and dampens neuroinflammation—you’ll find its track record in ALS research disappointingly underwhelming. The compound showed no survival benefit or motor improvement in SOD1(G93A) mouse models, the gold standard for preclinical ALS testing. While simpler organisms, such as C. elegans,…
Methylene Blue: A Ray of Hope for Alzheimer’s and Dementia Patients?
Reading Time: 4 minutes. Hey everyone in the Brain Health Blog Forum! I recently came across some intriguing research on Methylene Blue and its potential benefits for patients with Alzheimer’s and dementia. I thought it would be great to share what I’ve learned and see if anyone else here has any insights or experiences with…
Methylene Blue and the Immune System: Mechanisms, Evidence, and Considerations
Reading Time: 12 minutes. Methylene blue modulates immunity by inhibiting iNOS/NO signalling, suppressing NF-κB and inflammasome activation, and reducing the production of IL-1β, IL-18, IL-6, and MCP-1. It stabilises mitochondrial respiration as an alternative electron carrier, lowers ROS, and boosts ATP, aiding immune cell energetics. It tempers macrophage/neutrophil activation, as well as MMP release. Clinically,…
Navigating Neuroscience: Insights From Dr Daryl Wild
Reading Time: 6 minutes. Dr Daryl Wild’s journey from psychology to neuroscience exemplifies how personal experiences shape scientific expertise. You’ll find his shift was catalysed by family health challenges, leading to the establishment of the Okanagan Movement Disorder Clinic in 2015. His innovative approaches combine psychological insights with neurological applications, particularly in movement disorders and…
Unlocking Brain Health: Strategies for Vitality and Growth
Reading Time: 6 minutes. Our brains possess remarkable neuroplasticity, enabling continuous growth and adaptation throughout life. We can enhance cognitive function through targeted strategies, including quality sleep, stress management, and mentally stimulating activities. Neuroimaging research confirms that lifestyle interventions strengthen neural pathways and support cognitive resilience. We will reveal our neural potential by prioritising brain health through evidence-based…
Unlocking the Mysteries of Brain Function and Recovery
Reading Time: 7 minutes. Recent neuroscience research reveals the brain’s intricate role in perception and recovery through its network of 100 billion neurons. The brain doesn’t just process sensory input; it actively constructs our entire reality experience. While structural imaging shows physical changes, functional neuroscience demonstrates how neural circuits can be retrained after injury. Early…
